It is important to remember that pain itself can raise blood pressure through a stress response and changes in the nervous system. Measuring blood pressure while in pain may give higher than usual readings, so this should be borne in mind.
However, concerns have also been raised about whether painkillers themselves can paradoxically increase blood pressure. Studies have shown that some of these medicines raise blood pressure by a fraction, due to a small level of water retention.
This isn’t a problem for most people who take these medicines occasionally, or over a short-term period (a few days). However, someone with high blood pressure may want to avoid the risk associated with their blood pressure being higher for a sustained period if it can be avoided. A key point is that short term or occasional use of painkillers is usually not a concern and there is no evidence to suggest there is harm in this context.
Problems may primarily occur if individuals with high blood pressure find themselves using painkillers for more than a few days in a row to combat chronic pain problems. It can also cause problems in cases where certain medicines may interact to create a dramatic increase without the individual realising it.