Prostate Biopsy

A prostate biopsy is a procedure to remove a sample of suspicious tissue from the prostate to screen for prostate cancer.

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What is a prostate biopsy?

The prostate is a small, walnut-shaped gland found near the bladder in the male reproductive system. It produces and secretes fluid that nourishes, protects, and transports sperm (semen). 

A prostate biopsy is when a small sample of suspicious tissue is taken from within the prostate for testing. The sample is then examined under a microscope by a pathologist to check for cancer.

You might need a prostate biopsy if:

  • an MRI scan has found areas of unusual tissue in your prostate

  • a prostate-specific antigen (PSA) test shows levels higher than normal for your age

  • your consultant detects a lump or an abnormality during a rectal exam

  • you've had a previous biopsy with a normal result, but you still have elevated PSA levels

  • a previous biopsy revealed prostate tissue cells that were abnormal but not cancerous


At Welbeck, prostate biopsy is performed in our purpose-built Men’s Health centre by our experienced urology specialists.

What does a prostate biopsy involve?

There are 2 main types of prostate biopsy:

  • transrectal ultrasound (TRUS) guided biopsy – ultrasound waves are used to guide a needle through the rectum and into the prostate to collect tissue samples

  • transperineal biopsy – ultrasound waves are used to guide a needle through the skin between the testicles and the back passage (perineum) and into the prostate, to collect tissue samples

At Welbeck, we use the transperineal biopsy method, which is carried out by our consultant urologists. 

To begin, you’ll need to remove your clothing from the waist down and change into a hospital gown, which we will provide. Your consultant will then explain what’s going to happen.

You can expect the following for a prostate biopsy:

  1. When you’re ready, your consultant will ask you to lie back on the bed. To begin, a local anaesthetic with be injected into your perineum, which numbs the area.

  2. Your consultant will gently pass a lubricated ultrasound probe into your back passage to view the prostate gland via images on a screen.

  3. They will then use the ultrasound to guide a biopsy needle through the perineum and into the prostate. 

  4. Samples of tissue will be taken from the prostate, either from sections of the whole prostate, or a targeted area that’s been identified on a prior MRI scan.

  5. Once all the samples are taken, the biopsy needle and the probe will be removed.

After the procedure, the images will be examined and a report will be compiled. Your consultant will use these results to develop a treatment plan, which they will discuss with you.

What if my prostate biopsy results come back positive?

If cancer is found, this is likely to be a big shock for you. Our specialist consultants and staff are always on hand to help and support you.

The next steps will depend on how severe and advanced the cancer is. Further investigations may include:

  • PET scans

  • bone scans

  • CT scans

If your biopsy results are benign, but your PSA levels are raised, your consultant may suggest regular blood tests to monitor your levels over time.

What are the risks of a prostate biopsy?

A transperineal biopsy is a safe procedure and only uses a small dose of radiation. The benefits of detecting any potential problems far outweigh the minimal radiation risks.

Sometimes, a prostate biopsy can cause side effects, but symptoms should clear up soon after the procedure. These include:

  • pain or discomfort – felt in the back passage area (rectum), as a dull ache along the underside of your penis or lower stomach, or as bruising and discomfort in the area where the needle was inserted. This should only last a few days

  • mild bleeding – you may see a small amount of blood in your urine, bowel movements or semen for about 2 weeks after the biopsy. This should get better on its own

  • sexual problems – you might have problems getting or keeping an erection (erectile dysfunction), but this is rare and should get better within 2 months

  • difficulty passing urine – this can happen immediately after the procedure because the biopsy can cause the prostate to swell. Your doctor will make sure you can urinate before you go home 

It’s rare and much more likely to happen if you have a TRUS biopsy, but the procedure may cause a urine infection in some men. Symptoms include:

  • pain or a burning feeling when you urinate (pee)

  • dark or cloudy urine with a strong smell

  • needing to pee more urgently or more often than usual

  • pain in your lower stomach or back

See a doctor if you have any of these symptoms.

How to prepare for a prostate biopsy

To prepare for your prostate biopsy, you may need to:

  • provide a urine sample – to check if you have a urinary tract infection. If you do, your prostate biopsy will likely be postponed until the infection has cleared

  • stop taking certain medications 5 days beforehand – such as those that increase your risk of bleeding, including warfarin, aspirin, ibuprofen, and certain herbal supplements

  • do a cleansing enema at home – if this is needed, instructions will be provided beforehand

  • take antibiotics – taking these before your prostate biopsy can help prevent infection from the procedure

Specific preparation for a prostate biopsy can vary from person to person. When you make your appointment, you’ll be given all the details you need.

Recovery and aftercare

You can usually go home the same day of your prostate biopsy. It’s recommended to only take part in light activities for the next 1 to 2 days after the procedure.

You may need to take an antibiotic for a few days and avoid having anal sex for 2 weeks afterwards, or until any pain and discomfort has settled.

Take painkillers, such as paracetamol, for mild pain, but if any of the side effects last longer than they should, talk to your consultant.

How much does a private prostate biopsy cost?

Please contact our Men’s Health centre for pricing information.

Why choose Welbeck?

At Welbeck, our men’s health specialists are experts in their field and are dedicated to providing world-class care to every patient.

With access to colleagues across other specialties, our consultants are also able to refer within the Welbeck ecosystem if required to ensure you receive the treatment you need as quickly as possible, all under one roof.

All appointments, testing, treatment, and follow-up appointments take place within our state-of-the-art facilities, enabling us to deliver accurate diagnostics and advanced treatments.

Booking a private prostate biopsy

To book a prostate biopsy, you must be referred by either your GP or a urologist following a consultation with them. Self-referrals are not accepted for this test.

If you would like to schedule a consultation with a urologist, please get in touch to make an appointment. Your health is important to us, so we strive to offer same-day appointments whenever possible.

Our consultants are recognised by the major health insurance companies. If you have private health insurance, your treatment at Welbeck can begin once you have obtained authorisation. We also provide care to self-paying patients. Learn more about the different payment options at Welbeck.

FAQs

How long does a prostate biopsy take?

At Welbeck, a transperineal biopsy usually takes about 20 to 40 minutes. You will be able to go home as normal afterwards, but your consultant may ask you to wait until you’ve urinated. This is to make sure you can do so normally before you leave.

 

How many samples are taken during a prostate biopsy?

There are 2 main types of transperineal biopsy. A targeted transperineal biopsy takes just a few samples from the area of the prostate that looked unusual on the scan images from your MRI. A template transperineal biopsy takes up to 25 or more samples from different areas of the prostate.

 

What else can a prostate biopsy reveal?

As well as cancer, a prostate biopsy may find other changes to your prostate cells, called prostate intraepithelial neoplasia (PIN) or atypical small acinar proliferation (ASAP). Neither of these are cancer itself, but they can be a precursor to prostate cancer.

 

Do I need to fast before a prostate biopsy?

No, you can eat and drink as normal before a prostate biopsy.

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Prostate biopsy specialists

The specialists at OneWelbeck Men's Health use the latest innovations in healthcare to accurately diagnose and treat a wide range of urological conditions.