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Areas of Expertise

Professor David Holder specialises in Neurophysiology, carrying out Nerve Conduction Studies and Electromyography to measure nerve and muscle function in order to assist other specialists in their diagnosis and treatment of musculoskeletal and neurological conditions.



Conditions referred for these investigations include:

  • Carpal tunnel syndrome
  • Ulnar nerve entrapment at the wrist or elbow
  • Spinal radiculopathies where nerves are irritated as they leave the spinal cord
  • Muscle inflammation
  • Footdrop
  • Common peroneal nerve entrapment
  • Sciatica

Personal biography

Professor Holder jointly qualified in Clinical Medicine and Biophysics from Corpus Christi College, Cambridge and University College Hospital London. He then undertook a Master’s degree in Biophysics at the University of California, Berkeley and a PhD in Physiology at UCL. He held an MRC training fellowship and then Royal Society University Research Fellowship at University College London before taking a position as Consultant in Clinical Neurophysiology at the Middlesex Hospital and UCH.


Professor Holder has lead the Neurophysiology department at University College Hospital, London which undertakes EMG, EEG and nerve conduction studies since 1997. He also leads a multidisciplinary neurophysiology/bioengineering research group in Medical Physics at UCL. This is developing new methods to image function in the brain and peripheral nervous system and is currently funded by the Medical Research Council and National Institutes of Health USA. It has pioneered the new method of Electrical Impedance Tomography for this purpose. This provides a new tool in clinical neuroscience as it can provide 3D images of fast neural activity over milliseconds in the brain and peripheral nerves.

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